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The River Tame (Greater Manchester), not to be confused with its namesake in the West Midlands, rises on Denshaw Moor. Its catchment lies mainly on the western flank of the Pennines. The named river starts as compensation flow from Readycon Dean Reservoir in the moors above Denshaw. The source is a little further north, just over the county border in West Yorkshire, close to the Pennine Way. The highest point of the catchment is Greater Manchester's highest point at Black Chew Head.

The river flows generally south through Delph, Uppermill, Mossley, Stalybridge, Ashton-under-Lyne, Dukinfield, Haughton Green, Denton and Hyde. After Mossley the river marks much of the historical boundary dividing Cheshire and Lancashire, before its confluence with the River Goyt to form the River Mersey at Stockport.

The octagonal chimney, 210 feet (64m) high with an unusual tulip-shaped top was built in 1867 to serve Samuel Heginbottom's cotton-spinning mill which operated from 1831 to 1930. The mill itself was eventually demolished and replaced in recent years with canalside apartments called "Boatmans Walk". In 2000 the chimney was bought by Tameside Council and restored.