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The Manchester Ship Canal, which took six years to build and was opened in 1894, is a 36-mile-long inland waterway linking Manchester to the Irish Sea at Liverpool. It generally follows the original routes of the rivers Mersey and Irwell through the historic counties of Cheshire and Lancashire. Several sets of locks lift vessels about 60 feet up to the Manchester Docks (now Salford Quays), where the canal's terminus was built.

When the ship canal opened in January 1894 it was the largest river navigation canal in the world, and enabled the newly created Port of Manchester to become Britain's third busiest port despite the city being about 40 miles inland. Since its opening, the canal handled a wide range of ships and cargoes, from coastal vessels to intra-European shipping and inter-continental cargo liners; Manchester Liners established regular sailings by large ocean-going vessels.

The amount of freight carried by the canal peaked in 1958 at 18 million long tons but changes to shipping methods and the growth of containerisation during the 1970s and 1980s caused traffic to decline, resulting in the closure of the docks at Salford in 1984. Although able to accommodate a range of vessels from coastal ships to inter-continental cargo liners, the canal is no longer large enough for most modern vessels.

Salford Quays is an area of Salford, near the end of the Manchester Ship Canal. Previously the site of Manchester Docks, it became one of the first and largest urban regeneration projects in the United Kingdom following the closure of the dockyards in 1982. The Imperial War Museum. The Lowry & MediaCityUk are all located in the area.
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