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The Science and Industry Museum in Manchester is a large museum devoted to the development of science, technology and industry. It places particular emphasis on Manchester’s achievements and contributions in these fields.

The museum was originally called the North Western Museum of Science and Industry when it opened on Grosvenor Street in 1969 (SJ8497 : The North Western Museum of Science and Industry, Manchester). Having outgrown its former site, it was moved to its present location in Castlefield, where it opened on 15 September 1983. It later became known as The Museum of Science and Industry (MOSI) until its name was changed to the Science and Industry Museum in September 2018 to reflect it becoming part of the Science Museum Group.

The museum is housed in five listed buildings on the historic site of Liverpool Road Station which was vacated by British Rail in 1975. This station is the world’s oldest surviving passenger railway station; one of the original termini of the Liverpool and Manchester Railway, the world's first passenger railway.

The museum houses extensive displays on the themes of transport (railway locomotives and rolling stock, aircraft, and space vehicles), power (water, electricity, steam and gas engines), Manchester's sewerage and sanitation, textiles, communications and computing. There is currently no charge for entry to the museum.
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The Ordsall Chord (also known as the Ordsall Lane Chord, Ordsall Curve or Castlefield Curve) is a short stretch of railway line currently (2016/17) under construction in the Ordsall area of Salford. It will link the mainline railway stations at Manchester Piccadilly and Manchester Victoria.

First proposed in the 1970s (as the "Castlefield Curve"), parliamentary powers for construction of the link were received in 1979 but the project was cancelled. The proposal was revived in 2010 as part of Network Rail’s Manchester Northern Hub proposal. It is scheduled to be completed by December 2017, and will cost around £85 million to construct.